Curse
Curses are an in-game mechanic that either lowers the player's stats or bestows some other negative effect.
There are two different types of curses. 
Major Curse are strong, negative status effects that can not be stacked, and can only be received once per run even after removal. 
Minor Curse are weak, negative status effects that can be stacked. Stacked minor curses will only count as a single curse towards items such as 
Aphotic Charm, 
Twisted Blade and 
Absolution.
Curses can be Indestructible but only under special conditions
Curses
2. Ostiophobia
5. Sweaty Palms
8. Relic Eater
10. Item Eater
11. Tariffs
12. Inflation
13. Market Crash
14. Poverty
15. Low Stock
16. Blood Pact
17. Powder Shortage
18. Earthquakes
19. Rain of Fire
20. Waking Light
22. Fast Metabolism
23. Heat Wave
24. Hay Fever
25. Venomous
26. Plague
27. Tenderfoot
28. Empty Coffers
29. Rigged
30. The Crumbles
31. Poison Mushroom
32. Haunted Locks
33. Lethargy
34. Weakness
35. Imbalance
36. Wobbly
37. Mediocrity
38. Frailty
39. Enfeebled
40. Illness
41. Fever
42. Clumsiness
43. Ineptitude
44. Brittleness
45. Vulnerable
46. Blisters
47. Miner's Shoulder
48. Joint Pain
49. Arthritis
50. Spatial Sickness
51. Bottle Blight
52. Compulsion
53. Bottle Stopper
54. Mutation
55. Secrecy
56. Security Theater
58. Vertigo
59. Nullification
60. Dark Cloud
61. Uncreative
62. Malicious Intent
63. Bloodied Locks
64. Blood Offering
65. Debt
66. Momentary Peril
Removed
Getting and removing curses
Curses are inflicted by:
- opening a
Cursed Chest - destroying purple
Torches - praying at Altars
- taking deals from Offering Rooms or Sho'guul
- being haunted by 3
Will o' the Wisps - getting hit by Noori's homing cursed orbs
- Using
Siegfried's Aegis or 
Siegfried's Torment on a run (This will give Indestructible Curses) - The
Debt Curse is a special curse that can only be obtained in Othermine
A curse can be removed by:
Penance at Altars
Holy Water
Talisman
Purge Potion- Absolution
Purification Potion
Aether
Lesser Demon
History
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Trivia
- During development an idea was thrown around about a curse called Miner's Lung that stuns you every once and a while, this curse has not been created as of yet.